Neuropathic pain, caused by various central and peripheral nerve disorders, is especially problematic because of its severity, chronicity, and resistance to simple analgesics. The condition affects 2%–3% of the population, is costly to the health care system, and is personally devastating to the people who experience it.
In neuropathic pain, the nerve fibers may be damaged, dysfunctional, or injured. These damaged nerve fibers send incorrect signals to other pain centers. The impact of nerve fiber injury includes a change in nerve function both at the site of injury and areas around the injury.
Causes of Neuropathic Pain
Various conditions can affect nerves and may cause neuropathic pain as one of the features of the condition. These include the following:
• Trigeminal neuralgia.
• Back, leg, and hip problems
• Pain following shingles (post-herpetic neuralgia).
• Diabetic neuropathy – a nerve disorder that develops in some people with diabetes.
• Phantom limb pain following an amputation.
• Spine surgery
• Multiple sclerosis.
• Pain following chemotherapy.
• HIV infection.
• Atypical facial pain.
• Various other uncommon nerve disorders
Symptoms of Neuropathic Pain
Neuropathic pain symptoms may include:
• Shooting and burning pain
• Tingling and numbness
• Stabbing (lancinating)
• Extreme sensitivity to touch, even light touch
• Intermittent sharp pain
• Muscle weakness
In neuropathic pain the quality of life of affected person is diminished as the condition cause a substantial reduction in patient quality of life resulting in a vicious circle of pain, anxiety and sleep disturbance.
In addition, co-morbid conditions, such as depression are common and contribute to increased impairment & disability in patients’ daily activity.
Unfortunately, neuropathic pain often responds poorly to standard pain treatments and occasionally may get worse instead of better over time. For some people, it can lead to serious disability.
A multidisciplinary approach that combines therapies, however, can be a very effective way to provide relief from neuropathic pain.
What Amoun has for Neuropathic pain patients?
Amoun has registered pregabalin in Egypt and marketed it under name Irenypathic since Jan 2012.
Pregabalin was provisionally approved by the FDA in December 2004 for neuropathic pain associated with diabetic peripheral neuropathy, & post herpetic neuralgia
In June 2007, pregabalin became the first medication approved by the FDA specifically for the treatment of Fibromyalgia. & in June 2012 became the only molecule approved by the FDA for neuropathic pain accompanying Spinal cord injury.
Pregabalin modulates the hyper excited neurons, by Targets the a2-d subunit of voltage gated calcium channels2 and Reduces excessive release of excitatory neurotransmitters.
This mechanism of action is thought to account for the analgesic, anticonvulsant and anxiolytic activity of Pregabalin.
Pregabalin is recommended by international American and European guidelines as first line treatment for neuropathic pain
This molecules is highly accepted since been introduced to the market, as it has a favorable pharmacokinetics profile with minimal concern for drug-drug interaction and no interference with hepatic enzyme.
Ask your doctor for more details.