Consistent clinical improvement in fibromyalgia pain (1)
Potent SNRI:

Milnacipran inhibits Norepinephrine & Serotonin in a 3:1 ratio, which is the likely reason behind its analgesic properties. (4)
Well tolerated:
Unlike other psychotropic drugs, it is not excepected to have anticholinergic, sedative & cardiovascular effects as it is not directly affecting dopamine or other neurotransmitters (serotonergic, & B adrenergic, muscarinic, histamine, opiate, benzodiazepene &
aminobutyric acid). (2)