- Obesity management, including weight loss, and weight maintenance, in conjunction with dietary modification.
- Reducing weight for obese diabetic subjects
- Patients should be advised to adhere to dietary guidelines. If orlistat is taken with a meal very high in fat, the possibility of gastrointestinal side effects increases.
- Patients should be counseled to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition, because orlistat is shown to reduce the absorption of some fat-soluble vitamins and beta-carotene. The supplement should be taken at least 2 hours before or after an orlistat dose or at bedtime.
- Caution should be exercised when prescribing orlistat to patients with a history of hyperoxaluria or calcium oxalate nephrolithiasis.
- Weight-loss induction by orlistat may be accompanied by improved metabolic control in diabetics, which might require a reduction in the dose of oral hypoglycemic medication (e.g., sulfonylureas, metformin) or insulin.
- Orlistat adds to the lipid-lowering effect of pravastatin.