Slim-Safe

Composition: Each capsule contains orlistat120mg.

Properties:

Orlistat exerts a reversible inhibitory effect on gastric and pancreatic lipase in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases.

The inactivated enzymes are thus unavailable to hydrolyze dietary fat into absorbable free fatty acids and monoglycerides. The resulting caloric deficit has a positive effect on weight control. Systemic absorption of the drug is therefore not needed for its activity.

Pharmacokinetic Properties:  
-   Absorption of Orlistat after oral administration is minimal.
-    99% bound to plasma proteins (lipoproteins and albumin are the major binding proteins).
-    Half-life of the absorbed Orlistat is in the range of 1 to 2 hours.
-    Metabolism of Orlistat occurs mainly within the gastrointestinal wall. Two metabolites: M1 (4-member lactone ring hydrolyzed) and M3 (M1 with N-formyl leucine moiety cleaved) are known.
•    These metabolites are considered pharmacologically inconsequential.
•    The primary metabolite M1 has a short half-life (approximately 3 hours) whereas the secondary metabolite M3 disappears at a slower rate (half-life approximately 13.5 hours).
-    Fecal excretion of the unabsorbed drug was found to be the major route of elimination.

Indications: Slim-Safe^® is indicated for:
=    Obesity management, including weight loss and weight maintenance, in conjunction with dietary modification.
=    Reducing weight for obese diabetic subjects 

Contra-Indictions: Orlistat is contra-indicated in patients with chronic mal-absorption syndrome or cholestasis.  In addition to patients with known hypersensitivity to the product.

Adverse Effects:Gastrointestinal (G.I.) symptoms, including fecal urgency, flatulence and fatty stools are the most frequently reported adverse effects. They could be minimized by limiting the amount of fat in the diet. These side effects may last for less than 1 week, however the majority will not last more than 4 weeks.

Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels within 48 to 72 hours.

Other side effects such as headache, fatigue, anxiety and menstrual irregularities may happen.

Dosage & Administration: 120mg capsule (one capsule) three times a day with each main meal containing fat (during or up to 1 hour after the meal).  If a meal is occasionally missed or contains no fat, the dose of Slim-Safe® can be omitted.

Doses above 120mg three times a day have not been shown to provide additional benefit.

How supplied: Packs of one strip, each of 10 capsules.

• Ask a question about this product