Tamsul

Composition: Each modified-release capsule contains 0.4mg Tamsulosin hydrochloride.

Properties: -    Tamsulosin selectively blocks alpha-1 adreno-receptors (alpha1A-adrenoreceptor subtype) in the prostate, resulting in relaxation of prostatic and urethral smooth muscles. It is more selective than Prazosin.
-    Tamsul® increases the maximum urinary flow rate. It relieves obstruction by relaxing smooth muscle in prostate and urethra.
-    Pharmacokinetics
-    Tamsulosin is rapidly absorbed from the intestine and is almost completely bioavailable. The extent and rate of absorption are reduced by food. It peaks in plasma after 6 hours. Tamsulosin is about 99% bound to plasma proteins.
-    Tamsulosin is metabolized slowly in the liver primarily by Cytochrome P450 isoenzymes CYP2D6 and CYP3A4. None of the metabolites are more active than Tamsulosin itself.
-    Tamsulosin and its metabolites are mainly excreted through urine, with elimination half-life of 10-13 hours.

Indications: -   Treatment of urinary obstruction symptoms produced by benign prostatic hyperplasia.
  

Contra-Indictions: -    Hypersensitivity to Tamsulosin hydrochloride.
-    History of Postural hypotension.
-    Severe hepatic insufficiency.

Adverse Effects:-    Dizziness, headache, asthenia, postural hypotension and palpitations may rarely occur.
-    Postural hypotension may be exaggerated by exercise, heat or alcohol ingestion.
-    Because Tamsulosin is more selective on prostate than Prazosin, it shows less dilator effect (postural hypotension) than that seen with Prazosin.
-    So rarely, abnormal ejaculation may also occur.

Dosage & Administration: +    One capsule 0.4mg daily, to be taken after breakfast.
+    The dose may be increased, if necessary, after 2-4 weeks, to 0.8 mg daily.

How supplied: Strip contains 10 modified-release capsules in packs of one strip.

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