Ketolgin

Composition: SR capsules:    Each capsule contains 200mg Ketoprofen in S.R. pellet form.
Suppositories: Each suppository contains 100mg Ketoprofen.
Ampoules:        Each ampoule contains 100mg Ketoprofen.
Gel:                  2.5% Ketoprofen.

Properties: Ketoprofen (Ketolgin®) is a non-steroidal anti-inflammatory propionic acid derivative.  It rapidly relieves pain, reduces fever and decreases inflammation with high tolerability on the gastro-intestinal tract.  It is rapidly absorbed with a peak plasma concentration occurring about 0.5 to 2 hours after oral administration.  Ketolgin® is also well absorbed from the intramuscular and rectal routes. It could be administered also as an intravenous infusion. Plasma protein binding is 99%.  Substantial concentrations are found in synovial fluid. It is metabolized mainly by conjugation with glucuronic acid and is excreted in the urine.

Indications: -    Painful and inflammatory conditions e.g. headache, dysmenorrhea, dental pain, traumatic pain,  post-operatively, gouty pain and soft tissue disorders.
-    Rheumatic pain, musculoskeletal and joint disorders e.g. ankylosing spondylitis, osteoarthritis, sciatica and rheumatoid arthritis.  Also in peri-articular disorders, such as bursitis and tendinitis
-    Febrile conditions e.g. tonsillitis and pharyngitis

Contra-Indictions: -    Patients with known hypersensitivity to the drug.
-    Active peptic ulcer.
-    Patients in whom bronchospasm is precipitated by aspirin or other NSAIDs

Adverse Effects:Mild gastro-intestinal side effects that can be reduced by taking the drug with meals.

Dosage & Administration: SR capsules:     1 capsule (200 mg) once daily.
Suppositories: 1 suppository (100 mg) daily.
Ampoules:     1-2 ampoules daily (may be taken at 4 hours interval if necessary) up to a maximum of 200 mg daily intramuscularly or by intravenous infusion
Gel:         Apply 2-4 times daily on the affected area.

How supplied: SR Capsules:     Strips of 10 capsules in packs of 1 strip.
Suppositories: Packs of 5 suppositories.
Ampoules:     Packs of 3 ampoules.
Gel:     Tubes of 15 or 40gm Ketolgin® is also available in a fast acting tablet form 25mg and 50mg

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