Levoxin Tablets

Composition: Each film coated scored tablet contains: 500 or 250mg Levofloxacin.

Properties: Pharmacological Properties:
-    Levoxin® (Levofloxacin) is a new generation Fluoroquinolone with enhanced antimicrobial activity and tissue penetration. It is the levorotatory isomer of Ofloxacin and is twice as active as Ofloxacin.
-    Levoxin® is rapidly and completely absorbed after oral administration with a bioavailability reaching up to 99% after oral dose. Its absorption is not affected by food intake. Therefore it can be administered without regard to food.
-   Levoxin® has a wide distribution into body tissues and fluids especially into blister fluid, lung tissues, bile, gall bladder, prostate, testis, epididymis, semen and uterine tissues. About 25% of the oral dose is bound to plasma protein.
-    Levoxin® undergoes minimal hepatic metabolism and about 90% of the oral dose is excreted as unchanged drug in the urine with an elimination half-life of about 8 hours.

Indications: -    Acute maxillary sinusitis
-    Acute bacterial exacerbation of chronic bronchitis
-    Community acquired pneumonia due to typical or atypical bacteria
-    Hospital acquired pneumonia (Nosocomial pneumonia)
-    Complicated or uncomplicated skin and skin structure infections e.g. abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections.
-    Complicated or uncomplicated urinary tract infections
-    Upper UTI e.g. acute pyelonephritis
-    Lower UTI e.g. urethritis, cystitis or prostatitis
-    Typhoid fever and other enteric infections

Contra-Indictions: -    Hypersensitivity to Quinolones
-    Patients with a history of epilepsy especially those using  non-steroidal anti-inflammatory drugs
-    During pregnancy and breast feeding
-    Children and adolescent below the age of 18 years

Adverse Effects:In very rare cases, nausea, diarrhea or sleep disorders may occur.

Dosage & Administration: -    Acute maxillary sinusitis: 500mg once daily for 10-14 days.
-    Acute bacterial exacerbation of chronic bronchitis:  500mg once daily for 7 days.
-    Community acquired pneumonia:  500mg once daily for 7-14 days.
-    Hospital acquired pneumonia and complicated skin infections: 750mg once daily for 7-14 days.
-    Uncomplicated skin and skin structure infections: 500mg once daily for 7-10 days.
-    Complicated UTI:  250mg once daily for 10 days.
-    Uncomplicated UTI: 250mg once daily for 3 days.
-    Typhoid and other enteric infections: 500mg once daily for 5-7 days.
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Dose for patients with impaired renal function

 

How supplied: Levoxin® 500 or 250mg: Strips of 5 scored tablets in packs of 1 strip.

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